Quantitative pixelwise myocardial perfusion maps from first-pass perfusion MRI
نویسندگان
چکیده
منابع مشابه
Systolic 3D first-pass myocardial perfusion MRI
Introduction: First-pass myocardial perfusion imaging (MPI) is now an established tool for the assessment of ischemic heart disease, and the most widely used protocols involve 2D multi-slice acquisition. Three-dimensional (3D) MPI is potentially advantageous due to its contiguous spatial coverage and high SNR [1], and has been recently shown to be more accurate than 2D multi-slice techniques in...
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Methods A multi-slice saturation recovery (SR) pulse sequence with sequential SR time delays (TD) after a non-selective saturation pulse [2] was implemented at 3T (Fig. 1). The rationale for this acquisition scheme was to acquire a dedicated arterial input function (AIF) image with a short TD (50ms) in the aortic root and short-axis myocardial images with longer TD values (~150-400ms), to allow...
متن کاملMouse myocardial first-pass perfusion imaging
Figure 3: (left) First-pass perfusion images in a mouse with myocardial infarction. (right) Signal intensity-time curves extracted from three different ROIs. At time ‘A’, a lower rate of contrast agent uptake was seen in the infarcted myocardium, followed by a period of delayed-enhancement ‘B’. Figure 2: (top) Typical first-pass perfusion images in a healthy mouse. (bottom) Signal intensity-tim...
متن کاملQuantitative Perfusion Analysis of First-Pass Contrast Enhancement Kinetics: Application to MRI of Myocardial Perfusion in Coronary Artery Disease
PURPOSE Perfusion analysis from first-pass contrast enhancement kinetics requires modeling tissue contrast exchange. This study presents a new approach for numerical implementation of the tissue homogeneity model, incorporating flexible distance steps along the capillary (NTHf). METHODS The proposed NTHf model considers contrast exchange in fluid packets flowing along the capillary, incorpora...
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We used first-pass contrast-enhanced MRI to quantatively measure the myocardial Ktrans, a parameter indicating myocardial perfusion and vascular permeability, in mice with or without vasodilation. We measured a significant increase in myocardial Ktrans with vasodilation. We believe this may be the first report showing that first-pass imaging can quantify increased myocardial perfusion in mice r...
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ژورنال
عنوان ژورنال: The British Journal of Radiology
سال: 2014
ISSN: 0007-1285,1748-880X
DOI: 10.1259/bjr.20130727